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徐亮亮

发布时间：2020-03-13  点击：[]

徐亮亮研究员博士毕业于香港中文大学矫形外科与创伤学系。近十年专注于间充质干细胞的相关基础及应用研究，主要研究调控间充质干细胞增殖、干性和分化的基础因子及相关的信号传导途径；研究间充质干细胞在骨折愈合、软骨修复、肌腱修复等组织工程学的应用；研究骨科相关疾病如骨坏死、骨质疏松等的致病机制；并且利用荧光报告系统，以间充质干细胞为模型筛选中药中能促进或诱导干细胞成骨分化的有效成分。相关工作已发表38篇干细胞与再生医学相关的SCI文章，其中第一作者和通讯作者文章15篇，发表的杂志包括FASEB J、Sci Rep、Cell transplantation、Stem cell research & therapy、Stem Cells Dev、Oncotarget等。担任Biomaterials, Acta Biomaterialia、Evidence-Based Complementary and Alternative Medicine (eCAM)、Oncotarget、Cell death and diseases等杂志审稿人。参与3项国家自然科学基金面上项目（No：81172177，81371946，81774339）；主持1项国家自然科学基金的青年科学基金项目(24万, No: 31400834)。

主持或参加科研项目（课题）及人才计划项目情况：

1.暨南大学2017年度再生医学教育部重点实验室开放基金，绿原酸促进肢芽间充质干细胞构建组织工程软骨修复关节损伤的分子机制，资助金额：2万，在研，主持。

2.国家自然科学基金面上项目(批准号：81774339)，基于ChIP-Seq技术探讨组蛋白修饰在补肾法防治骨质疏松症中的表观遗传机制，2018.01-2021.12，资助金额：60万元。在研，参与。

3.广东省省级科技计划项目（项目编号: 2017A050506046），去成骨分化间充质干细胞生物学特性改变的机制及联合注射丹酚酸B修复骨质疏松性骨折的研究，2017-05-01至2020-04-30，资助金额：50万元。在研，主持。

4.自然科学基金青年科学基金项目(批准号：31400834) “Tenomodulin高表达的骨髓间充质干细胞促进肌腱愈合的机制及应用研究”，2015.01-2017.12,资助金额：24万元。在研，主持。

5.国家自然科学基金面上项目(批准号：81371946)，SOX11调控骨髓间充质干细胞分化与迁移的研究及其在骨/软骨再生中的应用，2014.01-2017.12，资助金额：70万元。在研，参与。

6.国家自然科学基金面上项目(批准号：81172177)，用胸腺嘧啶激酶基因修饰的间充质干细胞治疗肿瘤的研究，2012.01-2015.12，资助金额：55万元。参与，已结题。

已发表论文：

  1. Involvement of Tumor Necrosis Factor Alpha in Steroid-associated Osteonecrosis of the Femoral Head: friend or foe? Bin Fang#; Ding Wang; Jiaqian Zheng; Qiushi Wei; Dongxiang Zhan; Yamei Liu; Xuesong Yang; Haibin Wang; Gang Li*; Wei He*; Liangliang Xu*. Stem Cell Res Ther. 2019 Jan 3;10(1):5. doi: 10.1186/s13287-018-1112-x（IF:4.627，JCR分区：Q1）

  2. Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy. Liangliang Xu#, Weiping Lin, Longping Wen*, Gang Li*. Stem Cell Res Ther. Stem Cell Research & Therapy，volume 10, Article number: 219 (2019) （IF:4.627，JCR分区：Q1）

  3. Huo Xue Tong Luo capsule ameliorates osteonecrosis of femoral head through inhibiting lncRNA-Miat. Fang B, Li Y, Chen C, Wei Q, Zheng J, Liu Y, He W, Lin D, Li G, Hou Y*, Xu L*. J Ethnopharmacol. 2019 Apr 7:111862. doi: 10.1016/j.jep.2019.111862. [Epub ahead of print]（IF:3.414，JCR分区：Q1）

  4. Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats. Xu, Liangliang#; E, Shunmei; Lin, Sien; Hou, Yonghui; Lin, Weiping; He, Wei; Wang, Haibin*; Li, Gang*. CELL & TISSUE RESEARCH, 2019 Jan 8. doi: 10.1007/s00441-018-02979-4.（IF:3.360，JCR分区：Q3）

  5. Stearic acid methyl ester promotes migration of mesenchymal stem cells and accelerates cartilage defect repair. Yamei Liu#, Liangliang Xu#, Liuchao Hu#, Dongfeng Chen, Lijuan Yu, Xican Li, Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo*, Bin Wang*, Gang Li*. Journal of Orthopaedic Translation, Available online 23 October 2019. In Press, https://doi.org/10.1016/j.jot.2019.09.008（IF:3.063，JCR分区：Q1）

  6. MiR-539-5p negatively regulates migration of rMSCs induced by Bushen Huoxue decoction through targeting Wnt5a. Liuchao Hu#, Yamei Liu, Bin Wang, Zhifang Wu, Yingxiong Chen, Lijuan Yu, Junlang Zhu, Wei Shen, Chen Chen, Dongfeng Chen, Gang Li, Liangliang Xu* and Yiwen Luo*. Int J Med Sci. 2019 Jun 10;16(7):998-1006. doi: 10.7150/ijms.33437. eCollection 2019.（IF:2.333，JCR分区：Q2）

  7. Mesenchymal Stem Cells and Cancer: Clinical Challenges and Opportunities. Weiping Lin#, Linfeng Huang, Ying Li, Bin Fang, Gang Li*, Leilei Chen* and Liangliang Xu*. BioMed Research International, vol. 2019, Article ID 2820853, 12 pages, 2019. https://doi.org/10.1155/2019/2820853.（IF:2.197，JCR分区：Q3）

  8. Xu L,Liu Y, Sun Y, Wang B, Xiong Y, Lin W, Wei Q, Wang H, He W, Wang B, Li G. Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue. Stem Cell Res Ther. 2017 Dec 6;8(1):275. doi: 10.1186/s13287-017-0716-x.

  9. Hou Y, Ni M, Lin S, Sun Y, Lin W, Liu Y, Wang H, He W, Li G,Xu L. Tenomodulin highly expressing MSCs as a better cell source for tendon injury healing. Oncotarget. 2017 Aug 24;8(44):77424-77435. doi: 10.18632/oncotarget.20495. eCollection 2017 Sep 29.(Corresponding author)

  10. Shuo Huang,Liangliang Xu, Yuxin Sun, Sien Lin, Weidong Gu, Yamei Liu, Jinfang Zhang, Lin Chen and Gang Li. Systemic administration of allogeneic mesenchymal stem cells does not halt osteoporotic bone loss in ovariectomized rats. PloS One. 2016 Oct 6;11(10):e0163131. doi: 10.1371/journal.pone.0163131. eCollection 2016.(Co-first author)

  11. Fanbiao Meng,Liangliang Xu,Shuo Huang, Yang Liu, Yonghui Hou, Kuixing Wang, Xiaohua Jiang, Gang Li. Small nuclear ribonucleoprotein polypeptide N clone (sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2.Cell and tissue research. 2016 Oct;366(1):155-62. doi: 10.1007/s00441-016-2411-0. Epub 2016 May 17. (Co-first author)

  12. Huang S,Xu L, Sun Y, Zhang Y, Li G. The fate of systemically administrated allogeneic mesenchymal stem cells in mouse femoral fracture healing. Stem Cell Res Ther. 2015 Oct 26;6:206. doi: 10.1186/s13287-015-0198-7. PubMed PMID: 26503505; PubMed Central PMCID: PMC4621860.(Co-first author)

  13. Rui Y,Xu L, Chen R, Zhang T, Lin S, Hou Y, Liu Y, Meng F, Liu Z, Ni M, Tsang KS, Yang F, Wang C, Chan HC, Jiang X, Li G.Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells.Sci Rep.2015 Jun 8;5:11056. doi: 10.1038/srep11056.(Co-first author)

  14. Yuxin Sun,Liangliang Xu,Shuo Huang, Yonghui Hou, Yang Liu, Kai-Ming Chan, Xiao-Hua Pan, Gang Li. mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model.BioMed Research International, Volume 2015 (2015), Article ID 412327.(Co-first author)

  15. Shuo Huang,Liangliang Xu, Yifeng Zhang, Yuxin Sun, Gang Li.Systemic and local administration of allogeneic bone marrow derived mesenchymal stem cells promotes fracture healing in rats. Cell Transplantation.2015; 24(12):2643-55. doi: 10.3727/096368915X687219. Epub 2015 Feb 2.(Co-first author)

  16. Liangliang Xu, Shuo Huang, Yonghui Hou, Yang Liu, Ming Ni, Fanbiao Meng, Kuixing Wang, Yunfeng Rui, Xiaohua Jiang, and Gang Li. Sox11-modified mesenchymal stem cells (MSCs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of MSCs. FASEB Journal. 2015 Apr;29(4):1143-52. doi: 10.1096/fj.14-254169. Epub 2014 Dec 2.

  17. Liangliang Xu, Yang Liu, Yonghui Hou, Yinmei Wong, Gang Li. U0126 promotes osteogenesis of rat bone marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. Cell and Tissue Research. 2015 Feb;359(2):537-45. doi: 10.1007/s00441-014-2025-3. Epub 2014 Nov 4.

  18. Daohua Xu,Liangliang Xu, Chenhui Zhou, Wayne YW Lee, Tie Wu, Liao Cui, Gang Li. Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway. Int J Biochem Cell Biol.2014 Jun;51:1-9.(Co-first author)

  19. Liangliang Xu, Gang Li. Circulating mesenchymal stem cells and their clinical implications. Journal of Orthopaedic Translation, Volume 2, Issue 1, January 2014, Pages 1-7, http://dx.doi.org/10.1016/j.jot.2013.11.002.

  20. Xu LL, Meng FB, Ni M, Lee Y and Li G. N-cadherin regulates osteogenesis and migration of bone marrow-derived mesenchymal stem cells. Molecular Biology Reports 2013;40:2533-2539.

  21. Xu L, Song C, Ni M, Meng F, Xie H, Li G. Cellular retinol-binding protein 1(CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cellsthrough inhibiting RXRα-induced β-catenin degradation. Int J Biochem Cell Biol. 2012 Apr;44(4):612-9.

  22. Liangliang X, Yonghui H, Shunmei E, Shoufang G, Wei Z, Jiangying Z. Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity. Mol Biol Rep. 2010 Apr;37(4):1875-81.

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