岭南医学研究中心
 首页 | 中心概况 | 科研团队 | 科研设施 | 科研成果 | 合作交流 | 资料下载 
在职人员
您的位置： 首页>>科研团队>>在职人员>>正文

鲁路

发布时间：2020-03-13  点击：[]

 

 

鲁路，中西医结合临床博士，副研究员，硕士研究生导师，澳大利亚莫纳什大学心血管研究所访问学者，2017年进入广州中医药大学第一附属医院工作。现任中华中医药学会信息分会委员，中华中医药学会内科分会青年委员，中国中药协会肾病中药发展研究专业委员会委员，广东省中西医结合学会实验分会委员，广东省中西医结合学会肾衰竭分会委，Frontiers in Cell and Developmental Biology，Evidence-based Complementary and Alternative Medicine客座编辑。从事中医药信息化工具的建立与实践工作，发明中医药特色的数据模型及临床统计方法，建立了复方特色的中医药有效物质-靶点预测模型，及临床的中医药循证信息提取模型，拟在辩证论治的理论体系下，构建中医药的科学内涵。近五年以首位通讯作者在Cardiovascular Research，British journal of Pharmacology, Cell Death & Disease，Oncogenesis等上发表SCI论文20余篇，主持国家自然基金等省、市各级课题6项，发明专利2项。

研究方向：

  1. 中药复方靶点和有效成分的预测模型；

  2. 统计学习模型在中医临床和基础研究中的应用；

  3. 免疫细胞亚群在心脏病理中的作用；

学术任职

  1. 中华中医药学会信息分会委员

  2. 中华中医药学会内科分会青年委员

  3. 中国中药协会肾病中药发展研究专业委员会

  4. 广东省中西医结合学会实验分会委员

  5. 广东省中西医结合学会肾衰竭分会委员

  6. 广东省青年科学家协会青年委员

  7. 中国中西医结合学会科技志愿者总队青年会员

  8. 广东省自然医学会干细胞与中医再生医学专业委员会常务委员

  9. Frontiers in Cell and Developmental Biology，Evidence-based Complementary and Alternative Medicine客座编辑，参与多篇SCI论文审稿，国家自然基金/广东省科技项目评审专家。

主持科研项目

  1. 从CMø新亚群中鉴定益气养阴活血利水法治疗慢性心衰关键药效基础和优化，广州市科技计划，2021-2023，5万，主持，202102020269

  2. 建立适用复方的物质基础预测模型及基于心阴片调节慢性心衰CMø环境实践，广东省自然基金，2021-2023，10万，主持，2021A1515011457

  3. 从内皮细胞Nrf2-ARE调控网络鉴定真武汤对CRCS的作用靶点及组方优化，国家自然基金青年项目，2019.01-2021.12，20万，主持；81803928

  4. 从Nrf2调节网络中优化真武汤组方成分对CRCS治疗作用，广东省自然基金博士启动项目，2018.05-2021.04，10万，主持；2018A030310607

  5. 中医药作用物质基础研究，广州中医药大学杏林人才经费，2017-2020，40万，主持；

  6. IRF4诱导巨噬细胞极化在缺血/非缺血心脏病理中作用及靶向小分子药物筛选，广东省医学科研基金，2019-2021，主持，B2019028

专利

  1. 一种预测中药复方直接靶点和作用成分的方法，发明专利，申请号：201910562690.2

  2. 牛蒡子苷元在制备用于调控巨噬细胞分化的药物中的应用，发明专利，申请号：201910553009.8

出版

  1. 肾脏病饮食指南，辽宁科学技术出版社，副主编

  2. 近现代名中医肾病精华，辽宁科学技术出版社，秘书

通讯或第一作者论文

  1. 鲁路#, 倪世豪, 黄育生, 龙文杰, 唐雅琴, 王陵军, 杨忠奇. 探讨中药人用经验的临床数据类型和统计分析方法. 中国中药杂志, 2022.1:1-6

  2. Ni Shi-Hao #, Xu Jin-Dong #, Sun Shu-Ning, Li Yue, Zhou Zheng, Li Huan, Liu Xin, Deng Jian-Ping, Huang Yu-Sheng, Chen Zi-Xin, Feng Wen-Jun, Wang Jia-Jia, Xian Shao-Xiang, Yang Zhong-Qi *, Wang Sheng*, Wang Ling-Jun *, Lu Lu*. Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury. Cardiovascular Research,2021. 10.1093/cvr/cvab193.

  3. Sun Shu-Ning#, Ni Shi-Hao#, Li Yue#, Liu Xin, Deng Jian-Ping, Chen Zi-Xin, Li Huan, Feng Wen-Jun, Huang Yu-Sheng, Li Da-Nian, Xian Shao-Xiang, Yang Zhong-Qi, Wang Ling-Jun*, Lu Lu*. G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence. Cell Death & Disease, 2021, 12(6):594.

  4. Hu R, Wang MQ, Liu LY, You HY, Wu XH, Liu YY, Wang YJ, Lu L(*),Xiao W(*), Wei LB(*). Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. Journal of cellular and molecular medicine 2020;24: 11084-99. (并列通讯作者)

  5. Ni SH, Sun SN, Zhou Z, Li Y, Huang YS, Li H, Wang JJ, Xiao W, Xian SX, Yang ZQ, Wang LJ(*), Lu L(*). Arctigenin alleviates myocardial infarction injury through inhibition of the NFAT5-related inflammatory phenotype of cardiac macrophages/monocytes in mice. Laboratory investigation; a journal of technical methods and pathology 2020;100: 527-41.

  6. Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L(*), Wei LB(*). Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-kappaB/NLRP3 signaling pathway in AGEs-induced HUVECs. European journal of pharmacology 2020;867: 172797. (并列通讯作者)

  7. Bingxue Liang, Cui Yan，Lu Zhang, Zhongqi Yang, LingjunWang(*), Shaoxiang Xian(*), Lu Lu(*). The Effect of Acupuncture and Moxibustion on Heart Function in Heart Failure Patients: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2019, 6074967, 13.

  8. Ni SH, Sun SN, Huang ZY, Huang YS, Li H, Wang JJ, Xian SX, Yang ZQ, Wang LJ(*), Lu L(*). The pleiotropic association between IL-10 levels and CVD prognosis: Evidence from a meta-analysis. Cytokine 2019;119: 37-46.

  9. Huang ZY(#), Wang LJ(#), Wang JJ(#), Feng WJ, Yang ZQ, Ni SH, Huang YS, Li H, Yang Y, Wang MQ, Hu R, Wan H, Wen CJ, Xian SX(*), Lu L(*).Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1. British journal of pharmacology 2019;176: 267-81.

  10. Huang YF(#), Niu WB(#), Hu R(#), Wang LJ(#), Huang ZY(#), Ni SH, Wang MQ, Yang Y, Huang YS, Feng WJ, Xiao W(*), Zhu DJ(*), Xian SX(*), Lu L(*). FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3beta-related pathways. Oncogenesis 2018;7: 77.

  11. Wang M, Hu R, Wang Y, Liu L, You H, Zhang J, Wu X, Pei T, Wang F Lu L(*), Xiao W(*), Wei L(*). Atractylenolide III Attenuates Muscle Wasting in Chronic Kidney Disease via the Oxidative Stress-Mediated PI3K/AKT/mTOR Pathway. Oxidative medicine and cellular longevity 2019;2019: 1875471..(并列通讯作者)

  12. Wang M, Niu W, Hu R, Wang Y, Liu Y, Liu L, Zhong J, Zhang C, You H, Zhang J,Lu L(*)., Wei L(*), Xiao W(*). POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients. Molecular carcinogenesis 2018. 10.1002/mc.22966. (并列通讯作者)

  13. Hu R, Wang MQ, Niu WB, Wang YJ, Liu YY, Liu LY, Wang M, Zhong J, You HY, Wu XH, Deng N, Lu L(*)., Wei LB(*). SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway. Cancer cell international 2018;18: 183. (并列通讯作者)

  14. Wang LJ(#), Wang MQ(#), Hu R(#), Yang Y, Huang YS, Xian SX(*), Lu L(*). Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed research international 2017;2017: 1024769.

  15. Lu L(#), Huang YF(#), Wang MQ(#), Chen DX, Wan H, Wei LB, Xiao W(*). Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD. Asia Pacific journal of clinical nutrition 2017;26: 598-605.

  16. Lu L(#), Guo J(#), Hua Y(#), Huang K, Magaye R, Cornell J, Kelly DJ, Reid C, Liew D, Zhou Y, Chen A, Xiao W, Fu Q, Wang BH(*). Cardiac fibrosis in the ageing heart: Contributors and mechanisms. Clinical and experimental pharmacology & physiology 2017;44 Suppl 1: 55-63.

  17. Guo J(#), Lu L(#), Hua Y(#), Huang K, Wang I, Huang L, Fu Q, Chen A, Chan P, Fan H, Liu ZM, Wang BH(*). Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins. American journal of physiology Heart and circulatory physiology 2017;313: H1-H13. (共同第一作者)

  18. Lu L(#), Huang YF(#), Chen DX, Wang M, Zou YC, Wan H, Wei LB(*). Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats. Journal of ethnopharmacology 2016;186: 125-35.

  19. Huang YF(#), Lu L(#), Zhu DJ, Wang M, Yin Y, Chen DX, Wei LB(*). Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative medicine and cellular longevity 2016;2016: 9573291. (共同第一作者)

  20. Yin Y(#), Lu L(#), Wang D(#), Shi Y, Wang M, Huang Y, Chen D, Deng C, Chen J, Lv P, Wang Y, Li C, Wei LB(*). Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts. Cell biochemistry and biophysics 2015;73: 433-9.

  21. Lu L(#), Zou YC, Wang M, Huang YF, Chen DX, Wei LB(*). Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease. European journal of clinical nutrition 2015;69: 717-21.

  22. Lu L(#), Sun XM(#), Yin Y(#), Huang YF, Wang M, Wan H, Wei LB(*), Xiao W(*). The amino acid mutations of the podocin in proteinuria: a meta-analysis. Renal failure 2015;37: 1329-37.

  23. Lu L(#), Wan H, Yin Y, Feng WJ, Wang M, Zou YC, Huang B, Wang DT, Shi Y, Zhao Y, Wei LB(*). The p.R229Q variant of the NPHS2 (podocin) gene in focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome: a meta-analysis. Int Urol Nephrol 2014;46: 1383-93.

  24. Lu L(#), Wang DT, Shi Y, Yin Y, Wei LB(*), Zou YC, Huang B, Zhao Y, Wang M, Wan H, Li CJ, DiaoJX. Astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. International journal of biological macromolecules 2013;61: 7-16.

     

 

【关闭】

广州中医药大学 岭南医学研究中心  版权所有