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鲁路

发布时间:2020-03-13  点击:[]

鲁路,中西医结合临床博士,副教授,硕士研究生导师。研究方向为中药复方靶点虚拟筛选鉴定、有效成分预测及验证,中医药数据统计处理建模等方面。2016年以访问学者前往澳大利亚莫纳什大学心血管研究所,2017年进入广州中医药大学第一附属医院工作。近五年以第一或通讯作者在British journal of Pharmacology, Cell Death & Disease,Oncogenesis等上发表SCI论文15篇,被引用数百次,主持国家自然科学基金1项和省自然基金1项。

研究方向:

(1)中药复方靶点和有效成分的预测模型;

(2)统计学习模型在中医临床和基础研究中的应用;

(3)免疫细胞亚群在心脏病理中的作用;

(1)主持科研项目

①从内皮细胞Nrf2-ARE调控网络鉴定真武汤对CRCS的作用靶点及组方优化,国家自然基金青年项目,2019-2021,20万,主持;

从Nrf2调节网络中优化真武汤组方成分对CRCS治疗作用,广东省自然基金博士启动项目,2019-2021,10万,主持;

中医药作用物质基础研究,广州中医药大学杏林人才经费,2017-2020,40万,主持;

(2)通讯或第一作者论文

  1. Ni SH, Sun SN, Zhou Z, Li Y, Huang YS, Li H, Wang JJ, Xiao W, Xian SX, Yang ZQ, Wang LJ(*),Lu L(*). Arctigenin alleviates myocardial infarction injury through inhibition of the NFAT5-related inflammatory phenotype of cardiac macrophages/monocytes in mice. Laboratory investigation; a journal of technical methods and pathology 2019.

  2. Liang B, Yan C, Zhang L, Yang Z, Wang L(*) Xian S(*), Lu L(*). The Effect of Acupuncture and Moxibustion on Heart Function in Heart Failure Patients: A Systematic Review and Meta-Analysis. Evidence-based complementary and alternative medicine : eCAM 2019;2019: 6074967.

  3. Ni SH, Sun SN, Huang ZY, Huang YS, Li H, Wang JJ, Xian SX, Yang ZQ, Wang LJ(*),Lu L(*). The pleiotropic association between IL-10 levels and CVD prognosis: Evidence from a meta-analysis. Cytokine 2019;119: 37-46.

  4. Huang ZY(#), Wang LJ(#), Wang JJ(#), Feng WJ, Yang ZQ, Ni SH, Huang YS, Li H, Yang Y, Wang MQ, Hu R, Wan H, Wen CJ, Xian SX(*),Lu L(*). Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1. British journal of pharmacology 2019;176: 267-81.

  5. Huang YF(#), Niu WB(#), Hu R(#), Wang LJ(#), Huang ZY(#), Ni SH, Wang MQ, Yang Y, Huang YS, Feng WJ, Xiao W(*), Zhu DJ(*), Xian SX(*),Lu L(*). FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3beta-related pathways. Oncogenesis 2018;7: 77.

  6. Wang M, Niu W, Hu R, Wang Y, Liu Y, Liu L, Zhong J, Zhang C, You H, Zhang J,Lu L(*).,Wei L(*), Xiao W(*). POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients. Molecular carcinogenesis 2018. 10.1002/mc.22966.(并列通讯作者)

  7. Hu R, Wang MQ, Niu WB, Wang YJ, Liu YY, Liu LY, Wang M, Zhong J, You HY, Wu XH, Deng N,Lu L(*)., Wei LB(*). SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway. Cancer cell international 2018;18: 183.(并列通讯作者)

  8. Wang LJ(#), Wang MQ(#), Hu R(#), Yang Y, Huang YS, Xian SX(*),Lu L(*). Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed research international 2017;2017: 1024769.

  9. Lu L(#), Huang YF(#), Wang MQ(#), Chen DX, Wan H, Wei LB, Xiao W(*). Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD. Asia Pacific journal of clinical nutrition 2017;26: 598-605.

  10. Lu L(#), Guo J(#), Hua Y(#), Huang K, Magaye R, Cornell J, Kelly DJ, Reid C, Liew D, Zhou Y, Chen A, Xiao W, Fu Q, Wang BH(*). Cardiac fibrosis in the ageing heart: Contributors and mechanisms. Clinical and experimental pharmacology & physiology 2017;44 Suppl 1: 55-63.

  11. Guo J(#),Lu L(#), Hua Y(#), Huang K, Wang I, Huang L, Fu Q, Chen A, Chan P, Fan H, Liu ZM, Wang BH(*). Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins. American journal of physiology Heart and circulatory physiology 2017;313: H1-H13.(共同第一作者)

  12. Lu L(#), Huang YF(#), Chen DX, Wang M, Zou YC, Wan H, Wei LB(*). Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats. Journal of ethnopharmacology 2016;186: 125-35.

  13. Huang YF(#),Lu L(#), Zhu DJ, Wang M, Yin Y, Chen DX, Wei LB(*). Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative medicine and cellular longevity 2016;2016: 9573291.(共同第一作者)

  14. Yin Y(#),Lu L(#), Wang D(#), Shi Y, Wang M, Huang Y, Chen D, Deng C, Chen J, Lv P, Wang Y, Li C, Wei LB(*). Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts. Cell biochemistry and biophysics 2015;73: 433-9.

  15. Lu L(#), Zou YC, Wang M, Huang YF, Chen DX, Wei LB(*). Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease. European journal of clinical nutrition 2015;69: 717-21.

  16. Lu L(#), Sun XM(#), Yin Y(#), Huang YF, Wang M, Wan H, Wei LB(*), Xiao W(*). The amino acid mutations of the podocin in proteinuria: a meta-analysis. Renal failure 2015;37: 1329-37.

  17. Lu L(#), Wan H, Yin Y, Feng WJ, Wang M, Zou YC, Huang B, Wang DT, Shi Y, Zhao Y, Wei LB(*). The p.R229Q variant of the NPHS2 (podocin) gene in focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome: a meta-analysis. Int Urol Nephrol 2014;46: 1383-93.

  18. Lu L(#), Wang DT, Shi Y, Yin Y, Wei LB(*), Zou YC, Huang B, Zhao Y, Wang M, Wan H, Li CJ, Diao JX. Astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. International journal of biological macromolecules 2013;61: 7-16. 

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