鲁路，1987年9月29日生，中西医结合临床博士，莫纳什大学公共卫生学院访问学者，现任研究员、博士研究生导师，主要从事中医药在肾病治疗中的科研、教学与临床工作，研究方向涵盖中医药方法学及老年心肾疾病的实践。担任中华中医药学会内科分会青年委员、广东省中医药学会内科分会常务委员、广东省中西医结合学会肾病分会常务委员，以及《中华中医药杂志》青年编委。近五年在《Cardiovasc Res》《APSB》《Pharmacol Res》等期刊发表SCI论文40余篇，研究成果以欧洲心脏学会顶刊封面论文被专栏报道。获得中华中医药学会科技进步奖、中国中西医结合学会科技进步奖、广东省科技进步一等奖，入选广东省特支计划青年拔尖人才项目，中华中医药青年人才托举工程，获“求真学者”称号。现为单位中医药信息化揭榜挂帅团队负责人，入选中青年骨干人才培育项目菁英人才。同时，指导学生获得国家、省市级奖项超过10项，连续获得“优秀研究生导师”教学奖项。
(1) 研究方向：
① 中医临床和基础研究方法学；
② 中药复方靶点和有效成分的预测模型；
③ 免疫细胞亚群在老年疾病中的作用；
(2) 主持科研项目
① 融合中医证素辨识的老年跌倒风险智能预测系统及应用, 广东省中医药局应用研究, 202601281031129470，2026-01 至 2027-12, 25万元, 在研, 主持
② 中药产品全生命周期评价关键技术研究：人用经验关键技术及示范研究，国家重点研发计划， 2025.07-2028.06，500万，参与，2025YFC3507901
③ 从“重塑特异性EndoFP过程致心脏重构”角度探索益气解毒方治疗慢性心衰的关键药效机制，广州市科技计划，2025.01-2026.12，10万，主持，2025A04J5311
④ 从新亚群Rel-Mo/CD72hi-Mφ中探索真武汤对“阳虚湿浊”型慢性肾衰心脏损伤的疗效机制，国家自然基金面上项目，2024-2027，48万元，主持， 82374406
⑤ 基于尿毒症心肌病的CD72hi-MØ免疫环境探索真武汤“心肾同治”的关键药效机制，广东省教育厅高校科研项目，2024-2026，2.5万元，主持 2024KTSCX11
⑥ 2023年广州中医药大学第一附属医院中青年骨干人才培育项目，2023-2026，20万元，主持
⑦ 中医药防治慢性心力衰竭信息化团队，广州中医药大学青年创新拔尖人才团队培育揭榜挂帅项目，2023-2026，100万，主持
⑧ 基于单细胞测序探索新型EndoFP过程在慢性心力衰竭中的作用及暖心康调控的有效成分，广东省自然基金青年提升项目，2023.01-2025.12，30万，主持， 2023A1515030146
⑨ 建立适用复方的物质基础预测模型及基于心阴片调节慢性心衰CMø环境实践，广东省自然基金面上项目，2021.01-2024.12，10万，主持，2021A1515011457
⑩ 从CMø新亚群中鉴定益气养阴活血利水法治疗慢性心衰关键药效基础和优化，广州市科技计划，2021.01-2023.12，5万，主持，202102020269
⑪ 从内皮细胞Nrf2-ARE调控网络鉴定真武汤对CRCS的作用靶点及组方优化，国家自然基金青年项目，2019.01-2021.12，20万，主持；81803928
⑫ 从Nrf2调节网络中优化真武汤组方成分对CRCS治疗作用，广东省自然基金博士启动项目，2018.05-2021.04，10万，主持；2018A030310607
⑬ 中医药作用物质基础研究，广州中医药大学杏林人才经费，2017-2020，40万，主持；
⑭ IRF4诱导巨噬细胞极化在缺血/非缺血心脏病理中作用及靶向小分子药物筛选，广东省医学科研基金，2019-2021，自筹，主持，B2019028
(3) 获得称号
① 广东省特支计划“青年拔尖”人才计划项目，TZ09B77，中共广东省委人才工作领导小组
② 中华中医药学会青年人才托举工程项目，2021-QNRC2-B30，中华中医药学会
③ 第三批青年中医药求真学者，中医药志（真）2022Q024，《中华中医药杂志》
(4) 科研获奖
① 益气活血利水法治疗慢性心力衰竭的科学内涵探索及应用，中华中医药学会科学技术二等奖（排名3），2023
② 中药“人用经验”技术体系构建与推广应用，中国中西医结合学会科学技术三等奖（排名3），2023
③ 中药“人用经验”技术体系构建与推广应用，广东省科技进步一等奖（排名6），2024
(5) 教学相关
① 2024中国国际大学生创新大赛广东省银奖（硕博《心阳普照-中成药治疗心力衰竭的领跑者》）
② 2024中国国际大学生创新大赛全国铜奖（硕博《心阳普照-中成药治疗心力衰竭的领跑者》）
③ 2025中国国际大学生创新大赛广东省金奖（本科《心阳普照-中成药治疗心力衰竭的领跑者》）
(6) 专利
① 鲁路，倪世豪，孙术宁，一种预测中药复方直接靶点和作用成分的方法，发明专利，授权号： ZL201910562690.2
② 鲁路, 邓健平, 倪世豪, 孙术宁, 李悦, 刘欣, 欧阳小露. 一种基于图神经网络及组学信息的药物功效预测方法,发明专利，授权号：ZL202210206033.6
③ 鲁路, 黎欢, 刘欣, 倪世豪. 芍药新苷在制备治疗IV型肾心综合征的药物中的应用,发明专利，授权号：ZL202210579754.1
④ 鲁路, 倪世豪, 黎欢, 刘欣, 欧阳小露. 抑制骨桥蛋白表达的试剂在治疗尿毒症心衰中的应用，发明专利，授权号：ZL202210762109.3
⑤ 鲁路,陈星伶,倪世豪,李锦. 一种改善心肾功能衰退的中药组合物及其制备方法，申请号：CN 202411247898.2
⑥ 鲁路，倪世豪，孙术宁，牛蒡子苷元在制备用于调控巨噬细胞分化的药物中的应用，发明专利，申请号：CN201910553009.8
⑦ 鲁路，杨忠奇，倪世豪，张小娇.一种基于中药人用经验优化组合物的方法及高血压组合物，发明专利，申请号：CN2023114309325
(7) 出版
① 肾脏病饮食指南，辽宁科学技术出版社，副主编
② 近现代名中医肾病精华，辽宁科学技术出版社，秘书
(8) 通讯或第一作者论文
1) Xingling Chen, Qiangqiang Zhao, Linhuang Chen, Shengrong Lin, Bin Mai, Xingling He, Xiaojiao Zhang, Jiahui Chen, Sijing Li, Ziru Li, Hua Zhang, Yuehui Zhou, Xiaofang Li, Huili Liao, Taochun Ye, Shuning Sun, Zhongqi Yang, Shihao Ni, Lu Lu*, Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression, Acta Pharmaceutica Sinica B, 2026,
2) Li SJ, He XL, Zhang XJ, Li ZR, Liu HL, Zhang YH, Lu MQ, Chen JH, Dong XM, Long WJ, Lu L*, Yang ZQ*, Ni SH*. Immunometabolic reprogramming of macrophages: Emerging roles in skeletal muscle regeneration and therapeutic perspectives. Pharmacol Res. 2026;224:108109.
3) 鲁路,倪世豪,陈星伶,陈嘉慧,林声荣,吴之国,杨忠奇.人工智能赋能下基于人用经验的中药新药研发展望.中国中药杂志,1-10.doi:10.19540/j.cnki.cjcmm.20250708.601.
4) Sun SN, Liu X, Chen XL, Liang SL, Li J, Liao HL, Fang HC, Ni SH, Li Y*, Lu L*, Yang ZQ*, Wu H*, Wang LJ*. Calycosin alleviates myocardial fibrosis after myocardial infarction by restoring fatty acid metabolism homeostasis through inhibiting FAP. Phytomedicine. 2025;145:157045.
5) Chen XL, Zhao QQ, Lin SR, He XL, Zhang XJ, Li SJ, Li ZR, Chen JH, Zhang H, Li XF, Zhou YH, Liao HL, Sun SN, Yang ZQ, Ni SH, Lu L*. Epigenetic clocks as mediators of health behaviors and mortality in middle-aged and older adults. The journal of nutrition, health & aging. 2025;29(7):100602.
6) Li J, Chen XL, Ou-Yang XL, Zhang XJ, Li Y, Sun SN, Wang LJ, Yang ZQ, Ni SH, Lu L*. Association of tea consumption with all-cause/cardiovascular disease mortality in the chronic kidney disease population: an assessment of participation in the national cohort. Renal failure. 2025;47(1):2449578.
7) He X, Li Z, Li S, Zhang X, Liu D, Han X, He H, Chen J, Dong X, Long W, Lu H, Ye T, Meng F, Liao H, Yang Z, Lu L*, Ni S. Huoxue Tongluo tablet enhances atherosclerosis efferocytosis by promoting the differentiation of Trem2(+) macrophages via PPARgamma signaling pathway. Phytomedicine. 2025;140:156579.
8) Chen XL, Li J, Sun SN, Zhang XJ, Chen JH, Wang LJ, Yang ZQ, Ni SH, Lu L*. Validation of intrinsic capacity and healthy sleep pattern in middle-aged and older adults: a longitudinal Chinese study assessing healthy ageing. J Nutr Health Aging. 2024 Sep 21;28(11):100365. doi: 10.1016/j.jnha.2024.100365. Epub ahead of print. PMID: 39307073.
9) 倪世豪, 李姿儒, 李思静, 何星灵, 李锦, 陈星伶, 龙文杰, 张维维, 廖慧丽, 鲁路*, 杨忠奇. 基于单细胞测序研究心阳片改善尿毒症心肌病心肌纤维化的分子机制[J]. 中国中药杂志, 1-10.
10) Sun SN, Yao MD, Liu X, Li J, Chen XL, Huang WW, Ni SH, Ouyang XL, Yang ZQ, Li Y, Xian SX, Wang LJ, Lu Lu*. Trends in cardiovascular health among US adults by glycemic status based on Life's Essential 8. Preventive medicine. 2024:108042.
11) Li Y, Ni SH, Liu X, Sun SN, Ling GC, Deng JP, Ou-Yang XL, Huang YS, Li H, Chen ZX, Huang XF, Xian SX, Yang ZQ, Wang LJ, Wu HY, Lu L*. Crosstalk between endothelial cells with a non-canonical EndoMT phenotype and cardiomyocytes/fibroblasts via IGFBP5 aggravates TAC-induced cardiac dysfunction. Eur J Pharmacol. 2024 Mar 5;966:176378. doi: 10.1016/j.ejphar.2024.176378. Epub 2024 Feb 1. PMID: 38309679.
12) He X, Liu D, Ni S, Li Z, Li S, Wu T, Dong X, Zhang X, Tang Y, Ling Y, Liao H, Kang J, Li Y, Wu H, Luo J, Wan X, Zhang D, Lu L*, Long W, Yang Z. Efficacy and safety evaluation of Ginkgo biloba dropping pill (GBDP) on stable angina pectoris complicated with depression: A placebo-controlled, randomized, double-blind, multicenter study. Phytomedicine. 2024 Apr;126:155264. doi: 10.1016/j.phymed.2023.155264. Epub 2024 Jan 11. PMID: 38430820.
13) Zhang X. J., Han X. W., Jiang Y. H., Wang Y. L., He X. L., Liu D. H., Huang J., Liu H. H., Ye T. C., Li S. J., Li Z. R., Dong X. M., Wu H. Y., Long W. J., Ni S. H., Lu Lu*, Yang Z. Q. Impact of inflammation and anti-inflammatory modalities on diabetic cardiomyopathy healing: From fundamental research to therapy. International immunopharmacology. 2023;123:110747.
14) Xiao-Lu Ou Yanga†, Shi-Hao Nia†, Jin Lia†, Xiao-Jiao Zhanga, Si-Jing Lia, Yue Lia, Shu-Ning Sun, Xing-Ling He, Wen-Jie Long, Ling-Jun Wang, Zhong-Qi Yanga, Lu Lu*. Association of carbohydrate intake from different sources with all-cause and cardiovascular mortality among chronic kidney disease populations: Assessment of 1999-2018 National Health and Nutrition Examination Survey participation. International Journal of Food Sciences and Nutrition.2023, 10.1080/09637486.2023.2253005.
15) Li Y., Ling G. C., Ni R. B., Ni S. H., Sun S. N., Liu X., Deng J. P., Ou-Yang X. L., Li J., Xian S. X., Wang L. J., Ye T. C., Lu L*. Association of dietary total antioxidant capacity with all-cause and cardiovascular mortality in patients with chronic kidney disease: based on two retrospective cohort studies of NHANES. Renal failure. 2023;45(1):2205950.
16) 杨忠奇, 高蕊, 胡思源, 元唯安, 张磊, 唐健元, 邹冲, 李博, 李晓晖, 唐雅琴, 鲁路, 倪世豪. 中药人用经验研究专家共识[J]. 中国中药杂志, 2022,47(18):4829-4834.
17) 倪世豪, 刘晴晴, 康锦花, 龙文杰, 王陵军, 冼绍祥, 鲁路*, 杨忠奇*. 基于外周血免疫细胞转录组系统探索慢性心力衰竭阴虚证的炎症免疫环境[J]. 中华中医药杂志, 2022,37(11):6742-6747.
18) Shi-Hao Ni, Xiao-Jiao Zhang, Si-Jing Li, Xiao-Lu OuYang, Jin Li, Yue Li, Shu-Ning Sun, Xiao-Wei Han, Wen-Jie Long, Ling-Jun Wang*, Zhong-Qi Yang*, Lu Lu *,Lobetyolin Alleviates Ferroptosis of Skeletal Muscle in 5/6 Nephrectomized Mice via Activation of Hedgehog-GLI1 Signaling,Phytomedicine,2023, 10.1016/j.phymed.2023.154807
19) Deng, J.P., Liu, X., Li, Y., Ni, S.H., Sun, S.N., Ou-Yang, X.L., Ye, X.H.*, Wang, L.J.*, Lu Lu*., 2023. Drug vector representation and potential efficacy prediction based on graph representation learning and transcriptome data: Acacetin from traditional Chinese Medicine model. Journal of ethnopharmacology 305, 115966.
20) Ni SH, OuYang XL, Liu X, Lin JH, Li Y, Sun SN, Deng JP, Han XW, Zhang XJ, Li H, Huang YS, Chen ZX, Lian ZM, Wang ZK, Long WJ, Wang LJ*, Yang ZQ*, Lu Lu*: A molecular phenotypic screen reveals that lobetyolin alleviates cardiac dysfunction in 5/6 nephrectomized mice by inhibiting osteopontin. Phytomedicine 2022, 107:154412.
21) Liu X, Li Y, Ni SH, Sun SN, Deng JP, Ou-Yang XL, Huang YS, Li H, Chen ZX, Feng WJ, Lian ZM, Wang ZK, Xian SX, Yang ZQ, Ye XH, Wang LJ, Lu Lu*: Zhen-Wu decoction and lactiflorin, an ingredient predicted by in silico modelling, alleviate uremia induced cardiac endothelial injury via Nrf2 activation. J Ethnopharmacol 2022:115579.
22) 鲁路#, 倪世豪, 黄育生, 龙文杰, 唐雅琴, 王陵军, 杨忠奇. 探讨中药人用经验的临床数据类型和统计分析方法. 中国中药杂志, 2022.1:1-6
23) Ni Shi-Hao #, Xu Jin-Dong #, Sun Shu-Ning, Li Yue, Zhou Zheng, Li Huan, Liu Xin, Deng Jian-Ping, Huang Yu-Sheng, Chen Zi-Xin, Feng Wen-Jun, Wang Jia-Jia, Xian Shao-Xiang, Yang Zhong-Qi *, Wang Sheng*, Wang Ling-Jun *, Lu Lu*. Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury. Cardiovasc Res 2022, 118(5):1303-1320.
24) Sun Shu-Ning#, Ni Shi-Hao#, Li Yue#, Liu Xin, Deng Jian-Ping, Chen Zi-Xin, Li Huan, Feng Wen-Jun, Huang Yu-Sheng, Li Da-Nian, Xian Shao-Xiang, Yang Zhong-Qi, Wang Ling-Jun*, Lu Lu*. G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence. Cell Death & Disease, 2021, 12(6):594.
25) Hu R, Wang MQ, Liu LY, You HY, Wu XH, Liu YY, Wang YJ, Lu L(*),Xiao W(*), Wei LB(*). Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. Journal of cellular and molecular medicine 2020;24: 11084-99. (并列通讯作者)
26) Ni SH, Sun SN, Zhou Z, Li Y, Huang YS, Li H, Wang JJ, Xiao W, Xian SX, Yang ZQ, Wang LJ(*), Lu L(*). Arctigenin alleviates myocardial infarction injury through inhibition of the NFAT5-related inflammatory phenotype of cardiac macrophages/monocytes in mice. Laboratory investigation; a journal of technical methods and pathology 2020;100: 527-41.
27) Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L(*), Wei LB(*). Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-kappaB/NLRP3 signaling pathway in AGEs-induced HUVECs. European journal of pharmacology 2020;867: 172797. (并列通讯作者)
28) Bingxue Liang, Cui Yan，Lu Zhang, Zhongqi Yang, LingjunWang(*), Shaoxiang Xian(*), Lu Lu(*). The Effect of Acupuncture and Moxibustion on Heart Function in Heart Failure Patients: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2019, 6074967, 13.
29) Ni SH, Sun SN, Huang ZY, Huang YS, Li H, Wang JJ, Xian SX, Yang ZQ, Wang LJ(*), Lu L(*). The pleiotropic association between IL-10 levels and CVD prognosis: Evidence from a meta-analysis. Cytokine 2019;119: 37-46.
30) Huang ZY(#), Wang LJ(#), Wang JJ(#), Feng WJ, Yang ZQ, Ni SH, Huang YS, Li H, Yang Y, Wang MQ, Hu R, Wan H, Wen CJ, Xian SX(*), Lu L(*).Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1. British journal of pharmacology 2019;176: 267-81.
31) Wang M, Hu R, Wang Y, Liu L, You H, Zhang J, Wu X, Pei T, Wang F Lu L(*), Xiao W(*), Wei L(*). Atractylenolide III Attenuates Muscle Wasting in Chronic Kidney Disease via the Oxidative Stress-Mediated PI3K/AKT/mTOR Pathway. Oxidative medicine and cellular longevity 2019;2019: 1875471.(并列通讯作者)
32) Wang LJ(#), Wang MQ(#), Hu R(#), Yang Y, Huang YS, Xian SX(*), Lu L(*). Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed research international 2017;2017: 1024769.
33) Lu L(#), Huang YF(#), Wang MQ(#), Chen DX, Wan H, Wei LB, Xiao W(*). Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD. Asia Pacific journal of clinical nutrition 2017;26: 598-605.
34) Lu L(#), Guo J(#), Hua Y(#), Huang K, Magaye R, Cornell J, Kelly DJ, Reid C, Liew D, Zhou Y, Chen A, Xiao W, Fu Q, Wang BH(*). Cardiac fibrosis in the ageing heart: Contributors and mechanisms. Clinical and experimental pharmacology & physiology 2017;44 Suppl 1: 55-63.
35) Guo J(#), Lu L(#), Hua Y(#), Huang K, Wang I, Huang L, Fu Q, Chen A, Chan P, Fan H, Liu ZM, Wang BH(*). Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins. American journal of physiology Heart and circulatory physiology 2017;313: H1-H13. (共同第一作者)
36) Lu L(#), Huang YF(#), Chen DX, Wang M, Zou YC, Wan H, Wei LB(*). Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats. Journal of ethnopharmacology 2016;186: 125-35.
37) Huang YF(#), Lu L(#), Zhu DJ, Wang M, Yin Y, Chen DX, Wei LB(*). Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative medicine and cellular longevity 2016;2016: 9573291. (共同第一作者)
38) Yin Y(#), Lu L(#), Wang D(#), Shi Y, Wang M, Huang Y, Chen D, Deng C, Chen J, Lv P, Wang Y, Li C, Wei LB(*). Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts. Cell biochemistry and biophysics 2015;73: 433-9.
39) Lu L(#), Zou YC, Wang M, Huang YF, Chen DX, Wei LB(*). Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease. European journal of clinical nutrition 2015;69: 717-21.
40) Lu L(#), Sun XM(#), Yin Y(#), Huang YF, Wang M, Wan H, Wei LB(*), Xiao W(*). The amino acid mutations of the podocin in proteinuria: a meta-analysis. Renal failure 2015;37: 1329-37.
41)Lu L(#), Wan H, Yin Y, Feng WJ, Wang M, Zou YC, Huang B, Wang DT, Shi Y, Zhao Y, Wei LB(*). The p.R229Q variant of the NPHS2 (podocin) gene in focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome: a meta-analysis. Int Urol Nephrol 2014;46: 1383-93.
42)Lu L(#), Wang DT, Shi Y, Yin Y, Wei LB(*), Zou YC, Huang B, Zhao Y, Wang M, Wan H, Li CJ, DiaoJX. Astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. International journal of biological macromolecules 2013;61: 7-16.
