李静，女，教授，博导，广州中医药大学杏林杰出学者，英国利兹大学医学院永久性教职。主要从事钙离子信号调控血管平滑肌细胞增殖、迁移、凋亡等机制的分子生物学研究，血管内皮生长因子调节癌肿血管增生的病理学分子机理研究。尤其重要的是，在国际上首先发现了Piezo1这一压力感应蛋白对血管生成起到极其关键的作用,这一研究成果最近发表于Nature。已累计发表SCI论文数十篇，其中包括Nature, Nature Biotechnology, Molecular Cell, Circulation Research, ATVB, Cardiovascular Research, British Journal of Pharmacology等国际顶级及主流杂志，被引用数千余次。本人拥有十余年的临床经验，对心血管病的临床诊疗具有独到的见解。
研究方向：
1.心血管病的发病基因及调控分子机制研究
2.钙离子通道的功能研究
3.高通量筛选有效药物
联系方式：bmsjingl@gzucm.edu.cn
代表性著作：
1.Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM,Li J,Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.Nat Commun.2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.( impact factor12.124)
2.Abuarab N, Munsey TS, Jiang LH,Li J, Sivaprasadarao A.High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission.Sci Signal.2017 Aug 1;10(490). pii: eaal4161. doi: 10.1126/scisignal.aal4161.( impact factor6.494)
3.Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood NJ, Walker AM, Skromna A, Makova N, Galloway SL, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX,Li J, Beech DJ, Wheatcroft S, Cubbon RM, Kearney MT.Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop.Circ Res.2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.3096782016.( impact factor 15.211)
4.Peng H, Hao Y, Mousawi F, Roger S,Li J, Sim JA, Ponnambalam S, Yang X, Jiang LH.Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration.Stem Cells.2016 Aug;34(8):2102-14. doi: 10.1002/stem.2370.( impact factor 5.902)
5.Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y,Li J, Fishwick CW, Muraki K, Beech DJ, Bon RS.Natural and synthetic flavonoid modulation of TRPC5 channels.Br J Pharmacol.2016 Feb;173(3):562-74. doi: 10.1111/bph.13387.( impact factor 6.810)
6.Li J, Bruns A, Hou B et al, Orai3 surface accumulation and calcium entry evoked by vascular endothelial growth factor.Arteriosclerosis, Thrombosis, and Vascular Biology.2015 Sep;35(9):1987-94( impact factor 5.53)
7.Li J, Hou B, Beech DJ. Endothelial piezo1: Life depends on it.Channels(Austin). 2015 Jan 6:0.( impact factor 2.32)
8.Wilson LA, McKeown L, Tumova S,Li J, Beech DJ. A long variant of CRACR2A that belongs to the Rab GTPase protein family.Biochemical and Biophysical Research Communications.2015 Jan 2;456(1):398-402.( impact factor 2.50)
9.Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad KR, Evans PC, Ainscough JF, Beech DJ.Piezo1 integration of vascular architecture with physiological force.Nature. 2014 Nov 13;515(7526):279-82.( impact factor 42.35)
10.Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M,Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT.Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.Stem Cells. 2014 Oct;32(10):2714-23.( impact factor 7.133)
11.Amer MS, McKeown L, Tumova S, Liu R, Seymour VA, Wilson LA, Naylor J, Greenhalgh K, Hou B, Majeed Y, Turner P, Sedo A, O'Regan DJ,Li J, Bon RS, Porter KE, Beech DJ.Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.Br J Pharmacol.2013 Mar;168(6):1445-55.( impact factor 6.810)
12.Sukumar P, Sedo A,Li J, Wilson LA, O'Regan D, Lippiat JD, Porter KE, Kearney MT, Ainscough JF, Beech DJ.Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.Circ Res.2012 Jul 6;111(2):191-200.( impact factor 15.211 )
13.McKeown L, Moss NK, Turner P,Li J, Heath N, Burke D, O'Regan D, Gilthorpe MS, Porter KE, Beech DJ.Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.Circ Res.2012 Jun 22;111(1):66-76.( impact factor 15.211)
14.Li J, Fountain SJ.Fluvastatin suppresses native and recombinant human P2X4 receptor function.Purinergic Signal. 2012 Jun;8(2):311-6.( impact factor 3.51)
15.AL-Shawaf E, Tumova S, Naylor J, Majeed Y,Li J, Beech DJ.GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.Cell Calcium.2011 Oct;50(4):343-50.( impact factor 4.33)
16.Li J, McKeown L, Ojelabi O, Stacey M, Foster R, O'Regan D, Porter KE, Beech DJ.Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells.Br J Pharmacol.2011 Sep;164(2):382-93.( impact factor 6.810)
17.Li J, Cubbon RM, Wilson LA, Amer MS, McKeown L, Hou B, Majeed Y, Tumova S, Seymour VA, Taylor H, Stacey M, O'Regan D, Foster R, Porter KE, Kearney MT, Beech DJ.Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.Circ Res.2011 May 13;108(10):1190-8( impact factor 15.211)
18.*Cheong A,*Li J(* co-first authors), Sukumar P, Kumar B, Zeng F, Riches K, Munsch C, Wood IC, Porter KE, Beech DJ.Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers.Cardiovasc Res.2011 Feb 1;89(2):282-9.( impact factor 5.81)
19.Al-Shawaf E, Naylor J, Taylor H, Riches K, Milligan CJ, O'Regan D, Porter KE,Li J, Beech DJ.Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.Arterioscler Thromb Vasc Biol.2010 Jul;30(7):1453-9( impact factor 5.53)
20.Naylor J,Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, Sedo A, Yuldasheva N, Majeed Y, Beri D, Jiang S, Seymour VA, McKeown L, Kumar B, Harteneck C, O'Regan D, Wheatcroft SB, Kearney MT, Jones C, Porter KE, Beech DJ.Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.Circ Res.2010 May 14;106(9):1507-15( impact factor 15.211 )
21.Amer MS,Li J, O'Regan DJ, Steele DS, Porter KE, Sivaprasadarao A, Beech DJ.Translocon closure to Ca2+ leak in proliferating vascular smooth muscle cells.Am J Physiol Heart Circ Physiol.2009 Apr;296(4):H910-6.( impact factor 4.01)
22.Milligan CJ,Li J, Sukumar P, Majeed Y, Dallas ML, English A, Emery P, Porter KE, Smith AM, McFadzean I, Beccano-Kelly D, Bahnasi Y, Cheong A, Naylor J, Zeng F, Liu X, Gamper N, Jiang LH, Pearson HA, Peers C, Robertson B, Beech DJ.Robotic multiwell planar patch-clamp for native and primary mammalian cells.Nature Protoc.2009;4(2):244-55.( impact factor 12.423)
23.Li J, Sukumar P, Milligan CJ, Kumar B, Ma ZY, Munsch CM, Jiang LH, Porter KE, Beech DJ.Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells.Circ Res.2008 Oct 10;103(8):e97-104.( impact factor 15.211)
24.Xu SZ, Sukumar P, Zeng F,Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ.TRPC channel activation by extracellular thioredoxin.Nature.2008 Jan 3;451(7174):69-72.( impact factor 42.35)
25.Fountain SJ, Cheong A,Li J, Dondas NY, Zeng F, Wood IC, Beech DJ.K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress.Am J Physiol Heart Circ Physiol.2007 Nov;293(5):H2719-25.( impact factor 4.01)
26.*SZ, Muraki K, *Zeng F,*Li J(* co-first authors), Sukumar P, Shah S, Dedman AM, Flemming PK, McHugh D, Naylor J, Cheong A, Bateson AN, Munsch CM, Porter KE, Beech DJ.A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.Circ Res.2006 Jun 9;98(11):1381-9.( impact factor 15.211)
27.Flemming PK, Dedman AM, Xu SZ,Li J, Zeng F, Naylor J, Benham CD, Bateson AN, Muraki K, Beech DJ.Sensing of lysophospholipids by TRPC5 calcium channel.J Biol Chem.2006 Feb 24;281(8):4977-82.( impact factor 4.65)
28.Cheong A, *Bingham AJ,*Li J(* equal contributor), Kumar B, Sukumar P, Munsch C, Buckley NJ, Neylon CB, Porter KE, Beech DJ, Wood IC.Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.Mol Cell.2005 Oct 7;20(1):45-52.( impact factor 14.46)
29.Xu SZ, Zeng F, Lei M,Li J, Gao B, Xiong C, Sivaprasadarao A, Beech DJ.Generation of functional ion-channel tools by E3 targeting.Nat Biotechnol.2005 Oct;23(10):1289-93.( impact factor 39.10)
